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Year Number of Results
1997 1
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2001 5
2002 4
2003 6
2004 5
2005 10
2006 15
2007 8
2008 10
2009 14
2010 14
2011 8
2012 19
2013 22
2014 24
2015 35
2016 30
2017 30
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2020 31
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2022 25
2023 21
2024 7

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374 results

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Page 1
Rebalancing TGF-beta/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Yang Y, Sun M, Li W, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q, Li X, Wang H. Yang Y, et al. Clin Transl Med. 2021 Jul;11(7):e410. doi: 10.1002/ctm2.410. Clin Transl Med. 2021. PMID: 34323416 Free PMC article.
RESULTS: Based on meta-analysis results, CKI improved the liver function and relieved liver fibrosis among patients. In our preclinical studies by using two mouse models, CKI treatment demonstrated promising antifibrotic effects and postponed hepatocarcinogenesis wi …
RESULTS: Based on meta-analysis results, CKI improved the liver function and relieved liver fibrosis among patients. In our pr …
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis.
Xu F, Liu C, Zhou D, Zhang L. Xu F, et al. J Histochem Cytochem. 2016 Mar;64(3):157-67. doi: 10.1369/0022155415627681. Epub 2016 Jan 8. J Histochem Cytochem. 2016. PMID: 26747705 Free PMC article. Review.
In the context of hepatic fibrosis, SMAD3 and SMAD4 are pro-fibrotic, whereas SMAD2 and SMAD7 are protective. Deletion of SMAD3 inhibits type I collagen expression and blocks epithelial-myofibroblast transition. ...SMAD4 plays an essential role in fibrosis disease by enhan …
In the context of hepatic fibrosis, SMAD3 and SMAD4 are pro-fibrotic, whereas SMAD2 and SMAD7 are protective. Deletion of SMAD3 inhib …
Glycyrrhizic acid alleviates liver fibrosis in vitro and in vivo via activating CUGBP1-mediated IFN-gamma/STAT1/Smad7 pathway.
Guo M, Wang Z, Dai J, Fan H, Yuan N, Gao L, Peng H, Cheng X. Guo M, et al. Phytomedicine. 2023 Apr;112:154587. doi: 10.1016/j.phymed.2022.154587. Epub 2022 Dec 5. Phytomedicine. 2023. PMID: 36805480
Mechanistically, GA remarkably elevated the levels of IFN-gamma, p-STAT1, Smad7, and decreased CUGBP1 in vivo and in vitro. Over-expression of CUGBP1 completely abolished the anti-fibrotic effect of GA and regulation on IFN-gamma/STAT1/Smad7 pathway in LX-2 cells an …
Mechanistically, GA remarkably elevated the levels of IFN-gamma, p-STAT1, Smad7, and decreased CUGBP1 in vivo and in vitro. Over-expr …
Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl(4): roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.
Shu G, Yusuf A, Dai C, Sun H, Deng X. Shu G, et al. Food Funct. 2021 Nov 15;12(22):11686-11703. doi: 10.1039/d1fo02657g. Food Funct. 2021. PMID: 34730139
Herein, we assessed its effects on hepatocyte EMT and HSC activation in vitro and CCl(4)-elicited liver fibrosis in mice. Further experiments were performed to unveil the molecular mechanisms underlying the hepatoprotective activity of PIP. ...In mouse livers, PIP a …
Herein, we assessed its effects on hepatocyte EMT and HSC activation in vitro and CCl(4)-elicited liver fibrosis in mice. Further exp …
Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI.
Xu X, Guo Y, Luo X, Shen Z, Sun Z, Shen B, Zhou C, Wang J, Lu J, Zhang Q, Ye Y, Luo Y, Qu Y, Cai X, Dong H, Lu L. Xu X, et al. Liver Int. 2023 Nov;43(11):2523-2537. doi: 10.1111/liv.15715. Epub 2023 Aug 28. Liver Int. 2023. PMID: 37641479
The antifibrotic effect of hydronidone was further tested after Smad7 knockdown in HSCs in mouse models of fibrosis. RESULTS: In animal models, hydronidone attenuated liver damage and collagen accumulation, and reduced the expression of fibrosis-related genes. ...CO …
The antifibrotic effect of hydronidone was further tested after Smad7 knockdown in HSCs in mouse models of fibrosis. RESULTS: In anim …
Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl(4)-induced liver fibrosis in mice.
Shu G, Lei X, Li G, Zhang T, Wang C, Song A, Yu H, Wang X, Deng X. Shu G, et al. Food Funct. 2023 Nov 27;14(23):10591-10604. doi: 10.1039/d3fo03643j. Food Funct. 2023. PMID: 37955610
The activation of hepatic stellate cells (HSCs) is critically involved in the etiology of liver fibrosis (LF). Here, we report that in LX-2 HSCs, EGT upregulates the expression of Hint1 and Smad7 and suppresses their activation provoked by TGFbeta1. ...Mechanistical …
The activation of hepatic stellate cells (HSCs) is critically involved in the etiology of liver fibrosis (LF). Here, we report that i …
CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7.
Wang W, Dong R, Guo Y, He J, Shao C, Yi P, Yu F, Gu D, Zheng J. Wang W, et al. J Cell Mol Med. 2019 Aug;23(8):5486-5496. doi: 10.1111/jcmm.14432. Epub 2019 May 31. J Cell Mol Med. 2019. PMID: 31148365 Free PMC article.
The inhibitory effects of circMTO1 on HSC activation were suppressed by miR-17-5p mimics. Further studies showed that Smad7 was a target of miR-17-5p. Moreover, circMTO1-inhibited HSC activation was also blocked down by loss of Smad7. Taken together, we demonstrate …
The inhibitory effects of circMTO1 on HSC activation were suppressed by miR-17-5p mimics. Further studies showed that Smad7 was a tar …
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-beta1/Smad2/3 and activating IFN-gamma/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z. Liu Z, et al. Bioengineered. 2022 Apr;13(4):9357-9368. doi: 10.1080/21655979.2022.2054224. Bioengineered. 2022. PMID: 35387552 Free PMC article.
Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. ...Furthermore, GZFL remarkably elevated the levels of IFN-gamma, p-STAT1, and Smad7 in CCl(4)-treated mice. To sum up, GZFL was able to inhibit liver fibro …
Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. ...Furthermore, GZFL remarkabl …
Limonin relieves TGF-beta-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl(4)-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-beta/Smad cascade.
Shu G, Dai C, Yusuf A, Sun H, Deng X. Shu G, et al. J Nutr Biochem. 2022 Sep;107:109039. doi: 10.1016/j.jnutbio.2022.109039. Epub 2022 May 6. J Nutr Biochem. 2022. PMID: 35533902
Further studies revealed that limonin upregulated Smad7 and declined C-terminal phosphorylation and nuclear translocation of Smad2/3 to alleviate mouse CCl(4)-induced liver fibrosis. Our findings indicated that limonin inhibits TGF-beta-induced EMT of hepatocytes an …
Further studies revealed that limonin upregulated Smad7 and declined C-terminal phosphorylation and nuclear translocation of Smad2/3 …
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152.
Zhang R, Li X, Gao Y, Tao Q, Lang Z, Zhan Y, Li C, Zheng J. Zhang R, et al. J Ginseng Res. 2023 Jul;47(4):534-542. doi: 10.1016/j.jgr.2022.12.005. Epub 2022 Dec 29. J Ginseng Res. 2023. PMID: 37397418 Free PMC article.
Interestingly, Smad7, a negative regulator of the transforming growth factor beta (TGF-beta) pathway, is often methylated during liver fibrosis. Whether Smad7 methylation plays a vital role in the effects of Rg1 on liver fibrosis remains unclear. ...
Interestingly, Smad7, a negative regulator of the transforming growth factor beta (TGF-beta) pathway, is often methylated during l …
374 results